Internal Medicine
Online ISSN : 1349-7235
Print ISSN : 0918-2918
CASE REPORTS
An Adult Case of Anti-Myelin Oligodendrocyte Glycoprotein (MOG) Antibody-associated Multiphasic Acute Disseminated Encephalomyelitis at 33-year Intervals
Soichiro NumaTakashi KasaiTakayuki KondoYukie KushimuraAyaka KimuraHisashi TakahashiKanako MoritaAkihiro TanakaYu-ichi NotoTomoyuki OharaMasanori NakagawaToshiki Mizuno
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Keywords: MOG, ADEM, optic neuritis, adult
JOURNALS OPEN ACCESS

2016 Volume 55 Issue 6 Pages 699-702

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Abstract

Acute disseminated encephalomyelitis (ADEM) followed by optic neuritis (ON) has been reported as a distinct phenotype associated with anti-myelin oligodendrocyte protein (MOG) antibody. We herein report the case of a 37-year-old woman who was diagnosed with ADEM at 4 years old of age and who subsequently developed ON followed by recurrent ADEM 33 years after the initial onset. A serum analysis showed anti-MOG antibody positivity. This phenotype has only previously been reported in pediatric cases. Neurologists thus need to be aware that the phenotype may occur in adult patients, in whom it may be assumed to be atypical multiple sclerosis.

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© 2016 by The Japanese Society of Internal Medicine
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