Internal Medicine
Online ISSN : 1349-7235
Print ISSN : 0918-2918
Two Elderly Patients with Philadelphia Chromosome Positive Mixed Phenotype Acute Leukemia Who Were Successfully Treated with Dasatinib and Prednisolone
Hiroyuki TakataTaichi IkebeHitohiro SasakiYasuhiko MiyazakiEiichi OhtsukaYoshio SaburiMasao OgataKuniaki Shirao
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Volume 55 (2016) Issue 9 Pages 1177-1181

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Philadelphia chromosome positive (Ph+) mixed phenotype acute leukemia (MPAL) is a rare type of acute leukemia having both myeloid and lymphoid features for which no optimal treatment has yet been established. We herein describe two elderly Ph+MPAL patients who achieved molecular remission without any serious adverse events by treatment with dasatinib and prednisolone. Although dasatinib induction therapy combined with prednisolone is known to be a highly effective treatment for Ph+ acute lymphoblastic leukemia, its efficacy for Ph+MPAL has not been shown. The clinical courses of the present cases suggest that combination therapy with dasatinib and prednisolone is a safe and effective therapeutic modality in elderly Ph+MPAL patients.

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© 2016 by The Japanese Society of Internal Medicine
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