Multifocal Colonic Wall Abscesses during Anti-Tumor Necrosis Factor (TNF)-α Therapy for a Patient with Ulcerative Colitis: A Very Rare Manifestation of Infectious Complications

Toshiro Fukui; Mio Takahashi; Takashi Okazaki; Takashi Tomiyama; Norimasa Fukata; Yugo Ando; Kazuichi Okazaki

doi:10.2169/internalmedicine.56.8041

CASE REPORTS

Multifocal Colonic Wall Abscesses during Anti-Tumor Necrosis Factor (TNF)-α Therapy for a Patient with Ulcerative Colitis: A Very Rare Manifestation of Infectious Complications

Toshiro Fukui, Mio Takahashi, Takashi Okazaki, Takashi Tomiyama, Norimasa Fukata, Yugo Ando, Kazuichi Okazaki

Author information

Toshiro Fukui
The Third Department of Internal Medicine, Division of Gastroenterology and Hepatology, Kansai Medical University, Japan
Mio Takahashi
The Third Department of Internal Medicine, Division of Gastroenterology and Hepatology, Kansai Medical University, Japan
Takashi Okazaki
The Third Department of Internal Medicine, Division of Gastroenterology and Hepatology, Kansai Medical University, Japan
Takashi Tomiyama
The Third Department of Internal Medicine, Division of Gastroenterology and Hepatology, Kansai Medical University, Japan
Norimasa Fukata
The Third Department of Internal Medicine, Division of Gastroenterology and Hepatology, Kansai Medical University, Japan
Yugo Ando
The Third Department of Internal Medicine, Division of Gastroenterology and Hepatology, Kansai Medical University, Japan
Kazuichi Okazaki
The Third Department of Internal Medicine, Division of Gastroenterology and Hepatology, Kansai Medical University, Japan

Keywords: ulcerative colitis, biologics, adverse drug event, abscess

JOURNAL OPEN ACCESS

2017 Volume 56 Issue 10 Pages 1157-1161

DOI https://doi.org/10.2169/internalmedicine.56.8041

Details

Abstract

A 24-year-old woman was transferred to our hospital under suspicion of an exacerbation of her known ulcerative colitis. Colonoscopy revealed an edematous swelling and multifocal discharge of pus throughout the descending colon, concurrent with active ulcerative colitis findings in the rectum and sigmoid colon. Computed tomography showed a thickened wall and multifocal abscesses within the wall of the descending colon. Two weeks after starting antimicrobial therapy, she was discharged home. This is the first case report of multifocal colonic wall abscesses. In order not to increase the risk of serious infection associated with anti-TNF-α therapy, proper qualification and strict monitoring are essential.

Corresponding author

Register with J-STAGE for free!