The Successful Treatment of Refractory Polyarteritis Nodosa Using Infliximab

Satoko Matsuo; Keigo Hayashi; Eisaku Morimoto; Ayako Kato; Ken-Ei Sada; Haruki Watanabe; Mariko Takano-Narazaki; Katsue Sunahori-Watanabe; Tomoko Kawabata; Jun Wada

doi:10.2169/internalmedicine.56.8235

CASE REPORTS

The Successful Treatment of Refractory Polyarteritis Nodosa Using Infliximab

Satoko Matsuo, Keigo Hayashi, Eisaku Morimoto, Ayako Kato, Ken-Ei Sada, Haruki Watanabe, Mariko Takano-Narazaki, Katsue Sunahori-Watanabe, Tomoko Kawabata, Jun Wada

Author information

Satoko Matsuo
Department of Nephrology, Rheumatology, Endocrinology and Metabolism, Okayama University Graduate School of Medicine Dentistry and Pharmaceutical Sciences, Japan
Keigo Hayashi
Department of Nephrology, Rheumatology, Endocrinology and Metabolism, Okayama University Graduate School of Medicine Dentistry and Pharmaceutical Sciences, Japan
Eisaku Morimoto
Department of Nephrology, Rheumatology, Endocrinology and Metabolism, Okayama University Graduate School of Medicine Dentistry and Pharmaceutical Sciences, Japan
Ayako Kato
Department of Nephrology, Rheumatology, Endocrinology and Metabolism, Okayama University Graduate School of Medicine Dentistry and Pharmaceutical Sciences, Japan
Ken-Ei Sada
Department of Nephrology, Rheumatology, Endocrinology and Metabolism, Okayama University Graduate School of Medicine Dentistry and Pharmaceutical Sciences, Japan
Haruki Watanabe
Department of Nephrology, Rheumatology, Endocrinology and Metabolism, Okayama University Graduate School of Medicine Dentistry and Pharmaceutical Sciences, Japan
Mariko Takano-Narazaki
Department of Nephrology, Rheumatology, Endocrinology and Metabolism, Okayama University Graduate School of Medicine Dentistry and Pharmaceutical Sciences, Japan
Katsue Sunahori-Watanabe
Department of Nephrology, Rheumatology, Endocrinology and Metabolism, Okayama University Graduate School of Medicine Dentistry and Pharmaceutical Sciences, Japan
Tomoko Kawabata
Department of Nephrology, Rheumatology, Endocrinology and Metabolism, Okayama University Graduate School of Medicine Dentistry and Pharmaceutical Sciences, Japan
Jun Wada
Department of Nephrology, Rheumatology, Endocrinology and Metabolism, Okayama University Graduate School of Medicine Dentistry and Pharmaceutical Sciences, Japan

Keywords: infliximab, polyarteritis nodosa, rituximab

JOURNAL OPEN ACCESS

2017 Volume 56 Issue 11 Pages 1435-1438

DOI https://doi.org/10.2169/internalmedicine.56.8235

Details

Abstract

Polyarteritis nodosa (PAN), characterized by arteritis of medium-sized blood vessels, is usually treated with a combination of glucocorticoids and immunosuppressants; however, some cases are refractory to these treatments. We herein report the case of a man with PAN that was refractory to various immunosuppressive treatments, including cyclophosphamide, methotrexate, and rituximab. After infliximab (IFX) treatment was initiated, his symptoms improved dramatically and remission was maintained. IFX is considered to be an effective alternative treatment for PAN which proves to be refractory to several immunosuppressive treatments.

Corresponding author

Register with J-STAGE for free!