Internal Medicine
Online ISSN : 1349-7235
Print ISSN : 0918-2918
ISSN-L : 0918-2918
CASE REPORTS
Miliary Tuberculosis in a Young Woman with Hemophagocytic Syndrome: A Case Report and Literature Review
Mina AsajiKazunori TobinoKoujin MurakamiYuki GotoTakuto SueyasuSaori NishizawaKohei YoshimineMiyuki MunechikaYuki KoYuki YoshimatsuKosuke TsurunoHiromi IdeHiroyuki MiyajimaNoriyuki Ebi
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JOURNAL OPEN ACCESS

2017 Volume 56 Issue 12 Pages 1591-1596

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Abstract

We herein report a rare case of miliary tuberculosis-associated hemophagocytic syndrome (HPS) complicated with respiratory failure. A 19-year-old Japanese woman with a fever, general malaise, and chest radiograph abnormalities was referred to our hospital. After admission, she developed respiratory failure with pancytopenia. A histological examination of lung and bone marrow biopsy samples revealed noncaseating granulomas without evidence of acid-fast bacilli or lymphoma. In addition, a bone marrow biopsy showed marked histiocyte hyperplasia with hemophagocytosis, and a bronchoalveolar lavage fluid culture grew Mycobacterium tuberculosis. Therefore, a diagnosis of miliary tuberculosis-associated HPS was made. The patient was successfully treated with antituberculous therapy.

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© 2017 by The Japanese Society of Internal Medicine
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