Hypoglycemic Coma Induced by the Use of Succinic Acid Cibenzoline in Frail Late-stage Elderly Subjects

Yurie Hirata; Shinji Kamei; Fuminori Tatsumi; Masashi Shimoda; Akihito Tanabe; Junpei Sanada; Yoshiro Fushimi; Shintaro Irie; Tomoatsu Mune; Kohei Kaku; Hideaki Kaneto

doi:10.2169/internalmedicine.56.8120

CASE REPORTS

Hypoglycemic Coma Induced by the Use of Succinic Acid Cibenzoline in Frail Late-stage Elderly Subjects

Yurie Hirata, Shinji Kamei, Fuminori Tatsumi, Masashi Shimoda, Akihito Tanabe, Junpei Sanada, Yoshiro Fushimi, Shintaro Irie, Tomoatsu Mune, Kohei Kaku, Hideaki Kaneto

Author information

Yurie Hirata
Department of Diabetes, Endocrinology and Metabolism, Kawasaki Medical School, Japan
Shinji Kamei
Department of Diabetes, Endocrinology and Metabolism, Kawasaki Medical School, Japan
Fuminori Tatsumi
Department of Diabetes, Endocrinology and Metabolism, Kawasaki Medical School, Japan
Masashi Shimoda
Department of Diabetes, Endocrinology and Metabolism, Kawasaki Medical School, Japan
Akihito Tanabe
Department of Diabetes, Endocrinology and Metabolism, Kawasaki Medical School, Japan
Junpei Sanada
Department of Diabetes, Endocrinology and Metabolism, Kawasaki Medical School, Japan
Yoshiro Fushimi
Department of Diabetes, Endocrinology and Metabolism, Kawasaki Medical School, Japan
Shintaro Irie
Department of Diabetes, Endocrinology and Metabolism, Kawasaki Medical School, Japan
Tomoatsu Mune
Department of Diabetes, Endocrinology and Metabolism, Kawasaki Medical School, Japan
Kohei Kaku
Department of Diabetes, Endocrinology and Metabolism, Kawasaki Medical School, Japan
Hideaki Kaneto
Department of Diabetes, Endocrinology and Metabolism, Kawasaki Medical School, Japan

Keywords: succinic acid cibenzoline, hypoglycemic coma, drug concentration

JOURNAL OPEN ACCESS

2017 Volume 56 Issue 12 Pages 1527-1529

DOI https://doi.org/10.2169/internalmedicine.56.8120

Details

Abstract

Succinic acid cibenzoline (CZ) is an antiarrhythmic agent often used for the treatment of tachyarrhythmia. However, hypoglycemia should be avoided in the treatment of diabetes. We herein report two late-stage elderly subjects who experienced a severe and prolonged hypoglycemic coma after the usage of CZ. These cases suggest that, when CZ is administered to elderly subjects with renal dysfunction and/or frailty, we should be aware of the possibility that this medicine may induce hypoglycemia and should adjust the dose as appropriate and monitor the concentration of CZ to avoid severe hypoglycemia.

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