Internal Medicine
Online ISSN : 1349-7235
Print ISSN : 0918-2918
ISSN-L : 0918-2918
CASE REPORTS
A Rare Adult Case with Diffuse Segmental Membranous Glomerulonephritis
Yoshihide FujigakiYoshifuru TamuraShigeru ShibataFukuo KondoTakamasa IwakuraKenichiro KojimaYutaka YamaguchiShunya Uchida
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JOURNALS OPEN ACCESS

2017 Volume 56 Issue 13 Pages 1691-1695

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Abstract

A 71-year-old man with hypertension and diabetes mellitus presented with proteinuria. Laboratory data showed proteinuria of 3.1 g/g creatinine, serum albumin of 3.5 g/dL and serum creatinine of 1.03 mg/dL without autoantibodies. A renal biopsy revealed segmental granular IgG depositions on glomerular capillary walls. Electron microscopy showed segmentally subepithelial, intramembranous and mesangial deposits. Diffuse segmental membranous glomerulonephritis (MGN) was diagnosed with only IgG1 deposition and without M-type phospholipase A2 receptor or thrombospondin type-1 domain-containing 7A staining, suggesting secondary MGN with an unknown target antigen in immune deposits. Physicians should keep in mind the existence of segmental MGN to better understand the clinicopathological characteristics.

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© 2017 by The Japanese Society of Internal Medicine
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