Internal Medicine
Online ISSN : 1349-7235
Print ISSN : 0918-2918
ISSN-L : 0918-2918
CASE REPORTS
Histological Changes in Autoimmune Hepatitis with Graves' Disease: A Child Case Report
Mamiko YamadaHironori ShibataYohei MasugiTomohiro IshiKaori KameyamaHirotoshi EbinumaTomonobu Hasegawa
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JOURNALS OPEN ACCESS

2017 Volume 56 Issue 16 Pages 2139-2143

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Abstract

We herein report a child case of autoimmune hepatitis (AIH) accompanied with Graves' disease. Elevated aminotransferase levels were found in a 12-year-old Japanese girl with Graves' disease. In her first liver biopsy, necrosis and inflammation was limited to the centrilobular area, while the second biopsy showed different findings. Namely, portal injury newly appeared, including interface hepatitis, which represents the histological characteristics of AIH. As the histological findings at the onset of AIH do not always show typical findings, a re-biopsy is considered to be important in individuals suspected to have AIH. AIH should be included in the differential diagnosis of liver dysfunction in Graves' disease, even in children.

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© 2017 by The Japanese Society of Internal Medicine
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