Internal Medicine
Online ISSN : 1349-7235
Print ISSN : 0918-2918
ISSN-L : 0918-2918
Re-recognition of Age-dependent Reference Range for the Serum Creatinine Level in Teenagers - A Case of Slowly Progressive Tubulointerstitial Nephritis which Occurred in an Adolescent -
Hiroyuki OnoKojiro NagaiEriko ShibataMotokazu MatsuuraSeiji KishiTaizo InagakiMasanori MinatoSakiya YoshimotoSayo UedaFumiaki ObataKenji NishimuraMasanori TamakiFumi KishiTaichi MurakamiHideharu AbeYukiko KinoshitaMaki UrushiharaShoji KagamiToshio Doi
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2017 Volume 56 Issue 16 Pages 2187-2193


For the first time, a 15-year-old boy was found to have a slight degree of proteinuria and microscopic hematuria during annual school urinalysis screening. His kidney function had already severely deteriorated. A kidney biopsy revealed tubulointerstitial nephritis (TIN) with diffuse inflammatory cell infiltration. His medical records showed his serum creatinine level to be 0.98 mg/dL two years ago, which was abnormally high considering his age. Although the etiology of slowly progressive TIN was unclear, glucocorticoid and immunosuppressant therapy improved his kidney function. This case report suggests that all doctors should recognize the reference range for the serum creatinine level in teenagers.

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© 2017 by The Japanese Society of Internal Medicine
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