Internal Medicine
Online ISSN : 1349-7235
Print ISSN : 0918-2918
CASE REPORTS
Tocilizumab-resistant TAFRO Syndrome Complicated by Type II Respiratory Failure
Tatsuya AokiMikio WadaAtsushi KawashimaKouichi HirakawaAkihiro NagataKeizo Kagawa
Author information
JOURNALS OPEN ACCESS

2017 Volume 56 Issue 23 Pages 3249-3254

Details
Abstract

A 66-year-old man with a several year history of thrombocytopenia, pleural effusion and ascites, anasarca, and organomegaly presented with general fatigue, appetite loss, dyspnea with type II respiratory failure. The precise history of the patient and the re-evaluation of lymph node and bone marrow biopsies conducted by the previous physician indicated TAFRO syndrome. The patient's laboratory data improved for a year with tocilizumab, but then worsened to the point that the patient required artificial ventilation due to the deterioration of type II respiratory failure. The replacement of tocilizumab with rituximab yielded a steady improvement, but it was necessary to address the patient's persistent respiratory failure. Peripheral nerve disorder might have been involved with the patient's respiratory failure.

Information related to the author
© 2017 by The Japanese Society of Internal Medicine
Previous article Next article
feedback
Top