Hepatic Sinusoidal Obstruction Syndrome Induced by Non-transplant Chemotherapy for Non-Hodgkin Lymphoma

Miho Sakumura; Kazuto Tajiri; Shigeharu Miwa; Kohei Nagata; Kengo Kawai; Takayoshi Miyazono; Kotaro Arita; Akinori Wada; Jun Murakami; Toshiro Sugiyama

doi:10.2169/internalmedicine.56.7669

CASE REPORTS

Hepatic Sinusoidal Obstruction Syndrome Induced by Non-transplant Chemotherapy for Non-Hodgkin Lymphoma

Miho Sakumura, Kazuto Tajiri, Shigeharu Miwa, Kohei Nagata, Kengo Kawai, Takayoshi Miyazono, Kotaro Arita, Akinori Wada, Jun Murakami, Toshiro Sugiyama

Author information

Miho Sakumura
The Third Department of Internal Medicine, Toyama University Hospital, Japan
Kazuto Tajiri
The Third Department of Internal Medicine, Toyama University Hospital, Japan
Shigeharu Miwa
Diagnostic Pathology, Faculty of Medicine, University of Toyama, Japan
Kohei Nagata
The Third Department of Internal Medicine, Toyama University Hospital, Japan
Kengo Kawai
The Third Department of Internal Medicine, Toyama University Hospital, Japan
Takayoshi Miyazono
The Third Department of Internal Medicine, Toyama University Hospital, Japan
Kotaro Arita
The Third Department of Internal Medicine, Toyama University Hospital, Japan
Akinori Wada
The Third Department of Internal Medicine, Toyama University Hospital, Japan
Jun Murakami
The Third Department of Internal Medicine, Toyama University Hospital, Japan
Toshiro Sugiyama
The Third Department of Internal Medicine, Toyama University Hospital, Japan

Keywords: sinusoidal obstruction syndrome, chemotherapy, cyclophosphamide, jaundice, drug-induced liver injury

JOURNAL OPEN ACCESS

2017 Volume 56 Issue 4 Pages 395-400

DOI https://doi.org/10.2169/internalmedicine.56.7669

Details

Abstract

Hepatic sinusoidal obstruction syndrome (SOS), a serious complication that mainly occurs after hematopoietic-stem cell transplantation (HSCT), is caused by damage to the sinusoidal endothelial cells after the obstruction of the sinusoid. Recently, hepatic SOS was reported to occur after non-HSCT chemotherapies. This report describes a patient who experienced hepatic SOS after non-HSCT chemotherapy for non-Hodgkin lymphoma. A liver biopsy showed the slight dilatation of the hepatic sinusoid, which may be indicative of hepatic SOS. Hepatic SOS should be included in the differential diagnosis of patients with severe liver injury following the administration of chemotherapy regimens that are toxic to the vascular endothelial cells.

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