Pulmonary Artery Sarcoma Overexpressing Platelet-derived Growth Factor Receptor α

Shinnosuke Takemoto; Hiroshi Soda; Keisuke Iwasaki; Takeshi Kitazaki; Makoto Sumiyoshi; Tatsuhiko Harada; Yosuke Dotsu; Daiki Ogawara; Susumu Fukahori; Yuichi Fukuda; Hiroshi Mukae

doi:10.2169/internalmedicine.56.7731

CASE REPORTS

Pulmonary Artery Sarcoma Overexpressing Platelet-derived Growth Factor Receptor α

Shinnosuke Takemoto, Hiroshi Soda, Keisuke Iwasaki, Takeshi Kitazaki, Makoto Sumiyoshi, Tatsuhiko Harada, Yosuke Dotsu, Daiki Ogawara, Susumu Fukahori, Yuichi Fukuda, Hiroshi Mukae

Author information

Shinnosuke Takemoto
Department of Respiratory Medicine, Sasebo City General Hospital, Japan
Second Department of Internal Medicine, Nagasaki University School of Medicine, Japan
Hiroshi Soda
Department of Respiratory Medicine, Sasebo City General Hospital, Japan
Keisuke Iwasaki
Department of Pathology, Sasebo City General Hospital, Japan
Takeshi Kitazaki
Department of Respiratory Medicine, Sasebo City General Hospital, Japan
Department of Respiratory Medicine, Japan Red Cross Nagasaki Genbaku Hospital, Japan
Makoto Sumiyoshi
Department of Respiratory Medicine, Sasebo City General Hospital, Japan
Tatsuhiko Harada
Department of Respiratory Medicine, Sasebo City General Hospital, Japan
Yosuke Dotsu
Department of Respiratory Medicine, Sasebo City General Hospital, Japan
Daiki Ogawara
Department of Respiratory Medicine, Sasebo City General Hospital, Japan
Susumu Fukahori
Department of Respiratory Medicine, Sasebo City General Hospital, Japan
Yuichi Fukuda
Department of Respiratory Medicine, Sasebo City General Hospital, Japan
Hiroshi Mukae
Second Department of Internal Medicine, Nagasaki University School of Medicine, Japan

Keywords: pulmonary artery sarcoma, PDGFRα, PET/CT scans, endovascular catheter biopsy

JOURNAL OPEN ACCESS

2017 Volume 56 Issue 7 Pages 823-826

DOI https://doi.org/10.2169/internalmedicine.56.7731

Details

Abstract

Pulmonary artery sarcoma is highly malignant and easily metastasizes to the systemic organs. Both the introduction of novel diagnostic procedures and the development of new treatment modalities are required to achieve long-term survival. Several studies have shown that platelet-derived growth factor receptor α (PDGFRα) gene amplification is frequently observed in pulmonary artery sarcoma. PDGFRα is known to be involved in cell proliferation in certain malignancies. PDGFRα may become a potential biological marker in pulmonary artery sarcoma. We report a case in which a diagnosis of pulmonary artery sarcoma overexpressing PDGFRα was made using endovascular catheter biopsy following positron emission tomography with integrated computed tomography (PET/CT) scans.

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