Internal Medicine
Online ISSN : 1349-7235
Print ISSN : 0918-2918
ISSN-L : 0918-2918
CASE REPORTS
Progressive Restrictive Ventilatory Impairment in Idiopathic Diffuse Pulmonary Ossification
Hidemasa MatsuoTomohiro HandaMichiko TsuchiyaTakeshi KuboAkihiko YoshizawaYuko NakayamaShuichi ShigaTakefumi HitomiSouichi AdachiHiroshi DateToyohiro HiraiSatoshi Ichiyama
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JOURNALS OPEN ACCESS

2018 Volume 57 Issue 11 Pages 1631-1636

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Abstract

Diffuse pulmonary ossification (DPO) is a rare disease characterized by metaplastic bone formation in the lung. There are few reports with a long-term follow-up of this disease. We herein report a 47-year-old man diagnosed with idiopathic DPO at 30 years of age. The patient's vital capacity was normal until 36 years of age (3.39 L, 82.4% predicted), but it was severely decreased when he visited the hospital again at 47 years of age due to cough and dyspnea (1.98 L, 44.6% predicted). Chest computed tomography showed a significant increase in the number of high-density nodules, suggesting that the progression of DPO had caused restrictive ventilatory impairment.

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© 2018 by The Japanese Society of Internal Medicine
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