Internal Medicine
Online ISSN : 1349-7235
Print ISSN : 0918-2918
ISSN-L : 0918-2918
Amyotrophic Lateral Sclerosis after Receiving the Human Papilloma Virus Vaccine: A Case Report of a 15-year-old Girl
Ryota HikiamiHodaka YamakadoShinsui TatsumiTakashi AyakiYuichiro HashiHirofumi YamashitaNobukatsu SawamotoTeruyuki TsujiMakoto UrushitaniRyosuke Takahashi
ジャーナル オープンアクセス

2018 年 57 巻 13 号 p. 1917-1919


We herein report a 15-year-old girl who developed rapid progressive muscle weakness soon after the third injection of a bivalent human papilloma virus (HPV) vaccine. Although immunotherapies were performed for possible vaccine-related disorders, she died of respiratory failure 14 months after the onset of the disease. A genetic analysis identified a heterozygous p.P525L mutation of the fused in sarcoma (FUS) gene, and a histopathological analysis was also consistent with FUS-associated amyotrophic lateral sclerosis (ALS) without any evidence of neuroinflammation. We concluded the diagnosis to be FUS-ALS, although we cannot completely rule out the possibility that the vaccination worked as a trigger.

© 2018 by The Japanese Society of Internal Medicine
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