Internal Medicine
Online ISSN : 1349-7235
Print ISSN : 0918-2918
ISSN-L : 0918-2918
CASE REPORTS
Restoration of a Conduction Block after the Long-term Treatment of CIDP with Anti-neurofascin 155 Antibodies: Follow-up of a Case over 23 Years
Haruki KoikeRyoji NishiShohei IkedaYuichi KawagashiraMasahiro IijimaNaoki AtsutaTomohiko NakamuraMasaaki HirayamaHidenori OgataRyo YamasakiJun-ichi KiraMasahisa KatsunoGen Sobue
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JOURNALS OPEN ACCESS

2018 Volume 57 Issue 14 Pages 2061-2066

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Abstract

We herein report a woman with chronic inflammatory demyelinating polyneuropathy (CIDP) in whom positivity for anti-neurofascin 155 antibodies was revealed 23 years after the onset of neuropathy. The patient initially reported numbness in the face at 50 years of age and subsequently manifested features compatible to typical CIDP. Steroid administration initiated at 54 years of age ameliorated her neuropathic symptoms. Although the nerve conduction indices at 59 years of age deteriorated, those at 68, 72, and 73 years of age showed a gradual recovery. The deterioration and subsequent restoration of compound muscle action potential amplitudes was the most dramatic, suggesting that a conduction block can be reversed earlier than other electrophysiological indices.

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© 2018 by The Japanese Society of Internal Medicine
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