Internal Medicine
Online ISSN : 1349-7235
Print ISSN : 0918-2918
ISSN-L : 0918-2918
CASE REPORTS
A Japanese Encephalitis Patient Presenting with Parkinsonism with Corresponding Laterality of Magnetic Resonance and Dopamine Transporter Imaging Findings
Koh TadokoroYasuyuki OhtaKota SatoTakahiro MaekiRyo SasakiYoshiaki TakahashiJingwei ShangMami TakemotoNozomi HishikawaToru YamashitaChang Kweng LimShigeru TajimaKoji Abe
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JOURNAL OPEN ACCESS

2018 Volume 57 Issue 15 Pages 2243-2246

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Abstract

Japanese encephalitis (JE) survivors often present with nigrostriatal aftereffects with parkinsonian features. A 67-year-old woman with JE showed right-dominant clinical parkinsonism and left-dominant substantia nigra lesions after magnetic resonance imaging (MRI). Dopamine transporter (DAT) imaging using 123I-labeled 2β-carbomethoxy-3β-(4-iodophenyl)-N-(3-fluoropropyl)-nortropane (123I-FP-CIT) revealed a corresponding left-dominant decrease. The present case is the first to reveal a clear match of laterality between clinical parkinsonism, MRI-based substantia nigra lesions, and impaired DAT in presynaptic dopaminergic neurons in JE.

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© 2018 by The Japanese Society of Internal Medicine
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