A Patient with HCV Infection and a Sustained Virological Response to Direct-acting Antiviral Treatment Who Developed Inclusion Body Myositis

Toru Kuwano; Norio Akuta; Fumitaka Suzuki; Shunichiro Fujiyama; Yusuke Kawamura; Hitomi Sezaki; Tetsuya Hosaka; Satoshi Saitoh; Masahiro Kobayashi; Yoshiyuki Suzuki; Mariko Kobayashi; Yasuji Arase; Kenji Ikeda; Hiromitsu Kumada

doi:10.2169/internalmedicine.0585-17

CASE REPORTS

A Patient with HCV Infection and a Sustained Virological Response to Direct-acting Antiviral Treatment Who Developed Inclusion Body Myositis

Toru Kuwano, Norio Akuta, Fumitaka Suzuki, Shunichiro Fujiyama, Yusuke Kawamura, Hitomi Sezaki, Tetsuya Hosaka, Satoshi Saitoh, Masahiro Kobayashi, Yoshiyuki Suzuki, Mariko Kobayashi, Yasuji Arase, Kenji Ikeda, Hiromitsu Kumada

Author information

Toru Kuwano
Department of Hepatology, Toranomon Hospital, Japan
Norio Akuta
Department of Hepatology, Toranomon Hospital, Japan
Fumitaka Suzuki
Department of Hepatology, Toranomon Hospital, Japan
Shunichiro Fujiyama
Department of Hepatology, Toranomon Hospital, Japan
Yusuke Kawamura
Department of Hepatology, Toranomon Hospital, Japan
Hitomi Sezaki
Department of Hepatology, Toranomon Hospital, Japan
Tetsuya Hosaka
Department of Hepatology, Toranomon Hospital, Japan
Satoshi Saitoh
Department of Hepatology, Toranomon Hospital, Japan
Masahiro Kobayashi
Department of Hepatology, Toranomon Hospital, Japan
Yoshiyuki Suzuki
Department of Hepatology, Toranomon Hospital, Japan
Mariko Kobayashi
Liver Research Laboratory, Toranomon Hospital, Japan
Yasuji Arase
Department of Hepatology, Toranomon Hospital, Japan
Kenji Ikeda
Department of Hepatology, Toranomon Hospital, Japan
Hiromitsu Kumada
Department of Hepatology, Toranomon Hospital, Japan

Keywords: hepatitis C virus, inclusion body myositis, direct-acting antiviral, mixed cryoglobulinemia, sustained virological response

JOURNAL OPEN ACCESS

2018 Volume 57 Issue 17 Pages 2511-2515

DOI https://doi.org/10.2169/internalmedicine.0585-17

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Details

Abstract

We report the case of a 75-year-old woman who was found to have hepatitis C virus (HCV) infection in 1987. Before treatment in 2016, she was found to have mixed cryoglobulinemia (MC). Direct-acting antiviral (DAA) treatment produced a sustained virological response 12 (SVR12). She noticed gradual muscle weakness in 2015 and the gradual development of dysarthria and dysphagia in 2017. We performed a muscle biopsy that showed inclusion body myositis (IBM). To the best of our knowledge, this is first case of a patient with HCV infection, MC, and IBM, in which MC and IBM did not improve after an SVR12 was obtained by DAA treatment.

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