Internal Medicine
Online ISSN : 1349-7235
Print ISSN : 0918-2918
ISSN-L : 0918-2918
CASE REPORTS
Transient Pulmonary Interstitial Lesions in Aquaporin-4-positive Neuromyelitis Optica Spectrum Disorder
Yuko AsatoToshiaki KamitaniKuniyuki OotsukaMizuki KuramochiKozo NakanishiTetsuya ShimadaToshiyuki TakahashiTatsuro MisuMasashi AokiKazuo FujiharaYoshinori Kawabata
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JOURNALS OPEN ACCESS

2018 Volume 57 Issue 20 Pages 2981-2986

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Abstract

We herein report the case of a 76-year old man with aquaporin-4-Immunoglobulin-G (AQP4-IgG)-positive neuromyelitis optica spectrum disorder (NMOSD), in whom transient interstitial pulmonary lesions developed at the early stage of the disease. Chest X-ray showed multiple infiltrative shadows in both upper lung fields, and computed tomography revealed abnormal shadows distributed randomly in the lungs. Surgical lung biopsy showed features of unclassifiable interstitial pneumonia, characterized by various types of air-space organization, which resulted in obscure lung structure. This is the first report to describe the pathological findings of interstitial pneumonia, which may represent a rare extra-central nervous system complication of NMOSD.

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© 2018 by The Japanese Society of Internal Medicine
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