The Serum Ferritin Level Is Associated with the Treatment Responsivity for Rapidly Progressive Interstitial Lung Disease with Amyopathic Dermatomyositis, Irrespective of the Anti-MDA5 Antibody Level

Takeshi Osawa; Kozo Morimoto; Yuka Sasaki; Shuichi Matsuda; Kazunari Yamana; Ryozo Yano; Takashi Uchiyama; Hajime Goto

doi:10.2169/internalmedicine.8335-16

CASE REPORTS

The Serum Ferritin Level Is Associated with the Treatment Responsivity for Rapidly Progressive Interstitial Lung Disease with Amyopathic Dermatomyositis, Irrespective of the Anti-MDA5 Antibody Level

Takeshi Osawa, Kozo Morimoto, Yuka Sasaki, Shuichi Matsuda, Kazunari Yamana, Ryozo Yano, Takashi Uchiyama, Hajime Goto

Author information

Takeshi Osawa
Department of Respiratory Medicine, Fukujuji Hospital, Japan Anti-Tuberculosis Association, Japan
Kozo Morimoto
Department of Respiratory Medicine, Fukujuji Hospital, Japan Anti-Tuberculosis Association, Japan
Division of Clinical Research, Fukujuji Hospital, Japan Anti-Tuberculosis Association, Japan
Yuka Sasaki
Department of Respiratory Medicine, Fukujuji Hospital, Japan Anti-Tuberculosis Association, Japan
Shuichi Matsuda
Department of Respiratory Medicine, Fukujuji Hospital, Japan Anti-Tuberculosis Association, Japan
Kazunari Yamana
Department of Respiratory Medicine, Fukujuji Hospital, Japan Anti-Tuberculosis Association, Japan
Ryozo Yano
Department of Respiratory Medicine, Fukujuji Hospital, Japan Anti-Tuberculosis Association, Japan
Takashi Uchiyama
Department of Respiratory Medicine, Fukujuji Hospital, Japan Anti-Tuberculosis Association, Japan
Hajime Goto
Department of Respiratory Medicine, Fukujuji Hospital, Japan Anti-Tuberculosis Association, Japan

Keywords: amyopathic dermatomyositis, anti-clinically amyopathic dermatomyositis 140 antibody, anti-melanoma differentiation-associated gene 5 antibody, ferritin, polymyxin B direct hemoperfusion, rapidly progressive interstitial lung disease

JOURNAL OPEN ACCESS

2018 Volume 57 Issue 3 Pages 387-391

DOI https://doi.org/10.2169/internalmedicine.8335-16

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Abstract

We report the case of a 61-year-old woman with rapidly progressive interstitial lung disease caused by clinically amyopathic dermatomyositis. Both the serum ferritin and anti-melanoma differentiation-associated gene 5 (MDA5) antibody levels were elevated at the time of admission. Despite intensive treatment with corticosteroids, immunosuppressants, immunoglobulins and polymyxin B direct hemoperfusion, the patient died 75 days after symptom onset. Over the course of treatment, the anti-MDA5 antibody level continually decreased, while the serum ferritin level increased, suggesting that sequential measurements of the serum ferritin level might be useful for evaluating the treatment responsivity, irrespective of the anti-MDA5 antibody level.

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