Internal Medicine
Online ISSN : 1349-7235
Print ISSN : 0918-2918
ISSN-L : 0918-2918
CASE REPORTS
Prednisolone-responsive Postpartum IgG4-related Hypophysitis
Hisashi KoideAkina ShigaEri KomaiAzusa YamatoMasanori FujimotoAi TamuraTakashi KonoAkitoshi NakayamaTomoko TakiguchiSeiichiro HiguchiIkki SakumaHidekazu NaganoNaoko HashimotoSawako SuzukiYasuaki TakedaMakoto ShibuyaHiroshi NishiokaShozo YamadaNaoko InoshitaNorio IshiwatariKentaro HoriguchiKoutaro YokoteTomoaki Tanaka
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JOURNALS OPEN ACCESS

2018 Volume 57 Issue 3 Pages 367-375

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Abstract

We herein report the case of a 25-year-old woman who presented with severe headache and visual field defects after childbirth. Magnetic resonance imaging revealed marked swelling of the pituitary gland, and an endocrinological examination revealed panhypopituitarism and diabetes insipidus. An immunohistological analysis of a transsphenoidal biopsy sample of the pituitary gland showed the significant accumulation of an immunogloblin G4 (IgG4)-positive population, leading to the diagnosis of IgG4-related hypophysitis. The patient was treated with prednisolone, which markedly reduced the swelling of the pituitary gland, in association with recovery of the pituitary function. This is a rare case of biopsy-proven IgG4-related hypophysitis with a postpartum onset.

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© 2018 by The Japanese Society of Internal Medicine
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