The Impact of Human Parvovirus B19 Infection on Heart Failure and Anemia with Reference to Iron Metabolism Markers in an Adult Woman

Yuya Nakamura; Isao Ohsawa; Yoshikazu Goto; Hokuto Namba; Yusuke Dodo; Mayumi Tsuji; Yuji Kiuchi; Masahiro Inagaki; Hiromichi Gotoh

doi:10.2169/internalmedicine.8809-17

CASE REPORTS

The Impact of Human Parvovirus B19 Infection on Heart Failure and Anemia with Reference to Iron Metabolism Markers in an Adult Woman

Yuya Nakamura, Isao Ohsawa, Yoshikazu Goto, Hokuto Namba, Yusuke Dodo, Mayumi Tsuji, Yuji Kiuchi, Masahiro Inagaki, Hiromichi Gotoh

Author information

Yuya Nakamura
Department of Internal Medicine, Saiyu Soka Hospital, Japan
Department of Pharmacology, School of Medicine, Showa University, Japan
Isao Ohsawa
Department of Internal Medicine, Saiyu Soka Hospital, Japan
Yoshikazu Goto
Department of Internal Medicine, Saiyu Soka Hospital, Japan
Hokuto Namba
Department of Pharmacology, School of Medicine, Showa University, Japan
Yusuke Dodo
Department of Pharmacology, School of Medicine, Showa University, Japan
Mayumi Tsuji
Department of Pharmacology, School of Medicine, Showa University, Japan
Yuji Kiuchi
Department of Pharmacology, School of Medicine, Showa University, Japan
Masahiro Inagaki
Department of Chemistry, College of Arts and Sciences, Showa University, Japan
Hiromichi Gotoh
Department of Internal Medicine, Saiyu Soka Hospital, Japan

Keywords: human parvovirus B19, heart failure, anemia, growth differentiation factor-15, erythroferrone, hepcidin-25

JOURNAL OPEN ACCESS

2018 Volume 57 Issue 3 Pages 403-407

DOI https://doi.org/10.2169/internalmedicine.8809-17

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Abstract

A 35-year-old woman with fever, edema and rash was admitted. Pleural effusion and cardiomegaly were observed. A laboratory analysis revealed anemia with iron deficiency and elevated human parvovirus B19 (B19V) immunoglobulin M. The patient's hepcidin-25 and erythroferrone levels were not elevated compared to those observed later in her clinical course. On the other hand, her growth differentiation factor-15 (GDF-15) levels were elevated. She was diagnosed to have heart failure symptoms and anemia with specific iron metabolism abnormalities due to a B19V infection. After providing supportive treatment, the heart failure symptoms disappeared and her anemia had improved. This case emphasizes the need to include a B19V infection in the differential diagnosis when we encounter cases demonstrating reversible heart failure with anemia.

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