Internal Medicine
Online ISSN : 1349-7235
Print ISSN : 0918-2918
ISSN-L : 0918-2918
CASE REPORTS
Effects of the Concomitant Use of Low-dose Clarithromycin with an Anti-TNFα Antibody in a Patient with Intestinal Behçet Disease
Junichi IwamotoMasashi MurakamiNaoki KonishiTadakuni MonmaHajime UedaShoichiro YaraTakeshi HirayamaTadashi IkegamiAkira HondaYasushi Matsuzaki
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JOURNALS OPEN ACCESS

2018 Volume 57 Issue 3 Pages 339-342

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Abstract

A 66-year-old Japanese male with a history of Behçet disease exhibited oral and genital ulcers, and a round deep ileocecal ulcer. He was treated with a combination of mesalazine and 20 mg/day of prednisolone (PSL), but was only partially responsive to PSL and we were not able to reduce the steroid dosage. Adalimumab was also administered. However, the ulcer was not completely responsive, and weaning the patient off PSL remained impossible. In contrast, additional treatment with clarithromycin completely healed the refractory active ulcer and left only a scar. Furthermore, the ulcer has since maintained the scar stage despite successfully weaning the patient from PSL.

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© 2018 by The Japanese Society of Internal Medicine
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