Internal Medicine
Online ISSN : 1349-7235
Print ISSN : 0918-2918
ISSN-L : 0918-2918
CASE REPORTS
Seasonal Influenza Vaccine-induced Pneumonitis Presenting with Multiple Pulmonary Nodules
Takeshi NumataNorihito HidaKai YazakiNaoki AraiKyoko OtaHidetoshi YanaiTakeo Endo
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JOURNALS OPEN ACCESS

2018 Volume 57 Issue 5 Pages 707-711

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Abstract

A 39-year-old woman received a seasonal influenza vaccine in November 2015 and subsequently experienced malaise, low-grade fever, and chest discomfort. A chest X-ray performed 2 weeks after vaccination showed multiple nodular shadows in both lungs and ground-glass shadows in both lower lung fields. Her bronchoalveolar lavage fluid contained an unusually high number of lymphocytes, and a drug-induced lymphocyte stimulation test for seasonal influenza vaccine was positive. Transbronchial lung biopsy revealed the presence of granulomatous inflammation. Thereafter her abnormal chest shadow spontaneously improved. Based on these findings, the patient was diagnosed with drug-induced pneumonitis due to an influenza vaccine.

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© 2018 by The Japanese Society of Internal Medicine
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