Japanese Cardiovascular Disease Patients with Diabetes Mellitus Suffer Increased Tooth Loss in Comparison to Those without Diabetes Mellitus -A Cross-sectional Study

Norio Aoyama; Jun-ichi Suzuki; Naho Kobayashi; Tomoya Hanatani; Norihiko Ashigaki; Asuka Yoshida; Yuka Shiheido; Hiroki Sato; Hidetoshi Kumagai; Yuichi Ikeda; Hiroshi Akazawa; Issei Komuro; Masato Minabe; Yuichi Izumi; Mitsuaki Isobe

doi:10.2169/internalmedicine.9578-17

ORIGINAL ARTICLES

Japanese Cardiovascular Disease Patients with Diabetes Mellitus Suffer Increased Tooth Loss in Comparison to Those without Diabetes Mellitus -A Cross-sectional Study

Norio Aoyama, Jun-ichi Suzuki, Naho Kobayashi, Tomoya Hanatani, Norihiko Ashigaki, Asuka Yoshida, Yuka Shiheido, Hiroki Sato, Hidetoshi Kumagai, Yuichi Ikeda, Hiroshi Akazawa, Issei Komuro, Masato Minabe, Yuichi Izumi, Mitsuaki Isobe

Author information

Norio Aoyama
Division of Periodontology, Department of Oral Interdisciplinary Medicine, Graduate School of Dentistry, Kanagawa Dental University, Japan
Jun-ichi Suzuki
Department of Advanced Clinical Science and Therapeutics, The University of Tokyo, Japan
Department of Cardiovascular Medicine, Tokyo Medical and Dental University, Japan
Naho Kobayashi
Department of Periodontology, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University, Japan
Tomoya Hanatani
Department of Periodontology, Kyushu Dental University, Japan
Norihiko Ashigaki
Department of Oral Microbiology, Tsurumi University, Japan
Asuka Yoshida
Department of Periodontology, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University, Japan
Yuka Shiheido
Department of Periodontology, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University, Japan
Hiroki Sato
Department of Periodontology, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University, Japan
Hidetoshi Kumagai
Department of Advanced Clinical Science and Therapeutics, The University of Tokyo, Japan
Yuichi Ikeda
Department of Cardiovascular Medicine, The University of Tokyo, Japan
Hiroshi Akazawa
Department of Cardiovascular Medicine, The University of Tokyo, Japan
Issei Komuro
Department of Cardiovascular Medicine, The University of Tokyo, Japan
Masato Minabe
Division of Periodontology, Department of Oral Interdisciplinary Medicine, Graduate School of Dentistry, Kanagawa Dental University, Japan
Yuichi Izumi
Department of Periodontology, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University, Japan
Mitsuaki Isobe
Department of Cardiovascular Medicine, Tokyo Medical and Dental University, Japan

Keywords: periodontal disease, bacteria, diabetes mellitus, hemoglobin A1c

JOURNAL OPEN ACCESS

2018 Volume 57 Issue 6 Pages 777-782

DOI https://doi.org/10.2169/internalmedicine.9578-17

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Abstract

Objective Tooth loss is an irreversible condition that reflects the end-stage of oral diseases, including periodontitis. Although periodontitis is a major factor in the progression of diabetes mellitus (DM) and cardiovascular disease (CVD), no previous studies have compared tooth loss in CVD patients with and without DM.

Methods The subjects included CVD patients with (n=94) and without (n=145) DM who attended Tokyo Medical and Dental University Hospital. Blood examinations and periodontal measurements were performed.

Results The oral and periodontal examinations revealed that the numbers of missing teeth in the DM group were increased in comparison to the non-DM group. There was no significant difference between the groups with regard to the incidence of edentulism, the probing pocket depth, the clinical attachment level or the incidence of bleeding on probing.

Conclusion We showed that the numbers of missing teeth among CVD patients with DM was significantly higher than that among CVD patients without DM.

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