Internal Medicine
Online ISSN : 1349-7235
Print ISSN : 0918-2918
CASE REPORTS
A Rare Coexistence of Pheochromocytoma and Parkinson's Disease With Diagnostic Challenges
Erika Matsumura-MatsudaMotohiro SekiyaMiyoko Omoto-InuzukaKana SantoAkito ShikamaMotoko KubaYoko SuganoHitoshi IwasakiShigeru YatohTaiki SatoHisato HaraKazuhiro TakekoshiHiroaki SuzukiHitoshi Shimano
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JOURNALS OPEN ACCESS

2018 Volume 57 Issue 7 Pages 979-985

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Abstract

We herein report a case of pheochromocytoma occurring in the course of Parkinson's disease. The coexistence of these two disease is extremely rare, with only four cases hitherto reported across the public databases. It is also noteworthy that biochemical tests, which are critical for the diagnosis of pheochromocytoma, are severely confounded by dopaminergic medications for Parkinson's disease, highlighting the importance of image-based modalities in this setting. We further attempted to gain insight into the potential molecular mechanisms, proposing that hypoxia-inducible factor signaling could make these two diseases mutually exclusive, while excessive reactive oxygen species could enable their coexistence.

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© 2018 by The Japanese Society of Internal Medicine
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