Internal Medicine
Online ISSN : 1349-7235
Print ISSN : 0918-2918
ISSN-L : 0918-2918
CASE REPORTS
Glycogenic Hepatopathy in Type 1 Diabetes Mellitus
Shohei AsadaHideto KawarataniTsuyoshi MashitaniDaisuke KayaMaiko NishigoriTakuya KuboYasuhiko SawadaYukihisa FujinagaKosuke KajiMitsuteru KitadeTadashi NamisakiKei MoriyaAkira MitoroHitoshi Yoshiji
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JOURNAL OPEN ACCESS

2018 Volume 57 Issue 8 Pages 1087-1092

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Abstract

Glycogenic hepatopathy (GH) is a rare complication of poorly controlled type 1 diabetes mellitus (T1DM), and is characterized by elevated liver enzymes, hepatomegaly, and glycogen accumulation. We herein present the case of a 23-year-old man with poorly controlled T1DM who had liver dysfunction. Imaging studies showed severe hepatomegaly and fatty liver. The examination of a liver biopsy specimen revealed fatty droplets, ballooning, inflammation, and mild fibrosis. Subsequent periodic acid-Schiff (PAS) staining after diastase digestion confirmed GH. In this case, the improvement of hyperglycemia, not HbA1c, resulted in the improvement of the patient's liver function. This is the first report on the use of continuous glucose monitoring in patients with GH to show that continuous hyperglycemia may worsen GH.

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© 2018 by The Japanese Society of Internal Medicine
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