Internal Medicine
Online ISSN : 1349-7235
Print ISSN : 0918-2918
ISSN-L : 0918-2918
CASE REPORTS
An Acute Case of Granulomatous Amoebic Encephalitis-Balamuthia mandrillaris Infection
Kentarou TakeiMasaya ToyoshimaMasashi NakamuraMineshige SatoHiroshi ShimizuChihiro InoueYoshio ShimizuKenji Yagita
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ジャーナル オープンアクセス

2018 年 57 巻 9 号 p. 1313-1316

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A 74-year-old woman who exhibited drowsiness was referred to our hospital. Enhanced head magnetic resonance imaging (MRI) revealed multiple ring-enhancing lesions and lesions showing partial mild hemorrhaging. The patient gradually progressed to a comatose condition with notable brain deterioration of unknown cause on follow-up MRI. On day nine, the patient inexplicably died, although brain herniation was suspected. Autopsy and histopathology revealed numerous amoebic trophozoites in the perivascular spaces and within the necrotic tissue. Brain immunostaining tested positive for Balamuthia mandrillaris. Infection due to free-living amoeba is rare in Japan; however, it may increase in the near future due to unknown reasons.

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© 2018 by The Japanese Society of Internal Medicine
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