Internal Medicine
Online ISSN : 1349-7235
Print ISSN : 0918-2918
ISSN-L : 0918-2918
CASE REPORTS
Membranous Nephropathy with Crescent after Hematopoietic Cell Transplantation
Mineaki KitamuraSatoshi HisanoYuka KurobeShinichi AbeYuki OtaYasushi SawayamaTadashi UramatsuYoko ObataJunya FukuokaYasushi MiyazakiHiroshi MukaeTomoya Nishino
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JOURNAL OPEN ACCESS

2019 Volume 58 Issue 1 Pages 91-96

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Abstract

A 44-year-old man who received allogenic hematopoietic stem cell transplantation after being diagnosed with acute myeloid leukemia developed nephrosis when the dose of tacrolimus was tapered. A renal biopsy showed the granular deposition of immunoglobulin G in the glomerular basement membrane and subepithelial electron-dense deposits, crescent formation, C4d-positive staining of the peritubular capillary, and subendothelial swelling, suggesting that the main pathological diagnosis was membranous nephropathy and that chronic graft-versus-host disease played a role in the etiology of nephrosis. We herein report a case of membranous nephropathy with various pathological findings. C4d deposition suggests complement activation and the involvement of humoral factors.

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© 2019 by The Japanese Society of Internal Medicine
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