Internal Medicine
Online ISSN : 1349-7235
Print ISSN : 0918-2918
ISSN-L : 0918-2918
CASE REPORTS
Methotrexate-associated Lymphoproliferative Disorder: A Rare Differential Diagnosis of Wheezes
Mariko UjinoShoki MiyoshiNaoya SugimotoHidenori AraiYasunori OtaYuko SasajimaMasafumi KawamuraHiroyuki NagaseMasao YamaguchiKen Ohta
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JOURNALS OPEN ACCESS

2019 Volume 58 Issue 12 Pages 1759-1764

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Abstract

A 70-year-old woman was admitted for the evaluation of wheezes and a nodular lesion in the left lung field. She had been diagnosed with rheumatoid arthritis at 45 years of age and was continuously treated with methotrexate (MTX) at 8 mg/week. Bronchoscopic aspiration histology of a hilar lymph node suggested a lymphoproliferative disorder (LPD). After discontinuation of MTX, the lung nodule and wheezes disappeared. Although wheezes are not a usual manifestation of LPD, her clinical course clearly demonstrated an obvious relationship between LPD-induced airway narrowing and wheezes.

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© 2019 by The Japanese Society of Internal Medicine
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