Internal Medicine
Online ISSN : 1349-7235
Print ISSN : 0918-2918
ISSN-L : 0918-2918
Autoimmune Pulmonary Alveolar Proteinosis Diagnosed after Exposure to a Fire Extinguisher Containing Silica Powder
Takafumi YorozuyaKimiyuki IkedaHirofumi ChibaAtsushi SaitoKoji KuronumaHirotaka NishikioriSatsuki MiyajimaMamoru TakahashiTakumi YoshikawaYouhei TakahashiTetsuya TayaYuki MoriYasuaki UmedaMitsuo OtsukaHiroshi MoriyamaHiroki Takahashi
ジャーナル オープンアクセス

2019 年 58 巻 14 号 p. 2067-2072


We herein report a case of autoimmune pulmonary alveolar proteinosis (PAP) diagnosed after one-time exposure to silica powder. Owing to the misuse of a silica-containing fire extinguisher and the inhalation of large amounts of its powder, the patient experienced prolonged cough and visited our hospital. The findings of chest computed tomography and surgical lung biopsy specimens led to the diagnosis of PAP. Interestingly, the presence of anti-GM-CSF antibody was detected; therefore, both autoimmune characteristics and exposure to large amounts of silica may have caused the development of PAP in this patient. This case provides important insight into the mechanisms leading to the onset of PAP.

© 2019 by The Japanese Society of Internal Medicine
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