Internal Medicine
Online ISSN : 1349-7235
Print ISSN : 0918-2918
ISSN-L : 0918-2918
CASE REPORTS
Rapid and Long-term Response of Pulmonary Pleomorphic Carcinoma to Nivolumab
Satoru SenooTakashi NinomiyaGo MakimotoKazuya NishiiHirohisa KanoHiromi WatanabeYusuke HataToshio KuboTakehiro TanakaKatsuyuki HottaYoshinobu MaedaKatsuyuki Kiura
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JOURNALS OPEN ACCESS

2019 Volume 58 Issue 7 Pages 985-989

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Abstract

Pulmonary pleomorphic carcinoma (PPC) is a rare very aggressive subtype of non-small cell lung cancer. We herein report a case of PPC that showed a rapid response to nivolumab. The patient, whose multiple tumors had progressed very aggressively, was treated with nivolumab, an anti-programmed cell death-1 (PD-1) antibody. The tumors dramatically shrank after one cycle of nivolumab. The tumors were positive for programmed cell death ligand 1 (PD-L1). An immunohistochemical analysis revealed numerous PD-1+, CD68+ and CD206+ macrophages. This PD-1 antibody may be a good treatment option, especially in tumors that express PD-L1 and which show PD-1+ macrophage infiltration.

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© 2019 by The Japanese Society of Internal Medicine
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