Internal Medicine
Online ISSN : 1349-7235
Print ISSN : 0918-2918
ISSN-L : 0918-2918
CASE REPORTS
Metastatic Malignant Lymphoma Mimicking Cerebral Toxoplasmosis with the "Target Sign"
Hiroki UenoKazumi NoroseTeppei KamimuraKeichiro MiharaFumiyuki YamasakiKenji HikosakaVishwa J. AmatyaYukio TakeshimaKaoru KurisuHirofumi Maruyama
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JOURNALS OPEN ACCESS

2019 Volume 58 Issue 8 Pages 1157-1162

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Abstract

We herein report the case of a 60-year-old man with a "target sign" in the left frontal lobe on magnetic resonance imaging (MRI), which is thought to be a specific sign of cerebral toxoplasmosis. 18F-fluorodeoxyglucose-positron emission tomography showed no increased uptake, and 201Tl-single photon emission computed tomography showed the focal uptake in the left frontal lesion. On a brain biopsy, the patient was given a definitive diagnosis of brain metastasis from diffuse large B-cell lymphoma, and cerebral toxoplasmosis was excluded. In the present case, multilayer intensities on MRI may reflect the fast-growing nature of this tumor.

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© 2019 by The Japanese Society of Internal Medicine
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