Internal Medicine
Online ISSN : 1349-7235
Print ISSN : 0918-2918
ISSN-L : 0918-2918
CASE REPORTS
Pazopanib Confers a Progression-free Survival in a Patient with Ewing's Sarcoma/Primitive Neuroectodermal Tumor of the Lung
Ayako TakigamiHideaki YamasawaAyako KurosakiNoritaka SakamotoTsugitoshi OnukiNaoko MatoKenji TetsukaShunsuke EndoToshiro NikiMasashi BandoKoichi Hagiwara
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JOURNAL OPEN ACCESS

2019 Volume 58 Issue 9 Pages 1335-1339

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Abstract

Ewing's sarcoma (ES)/primitive neuroectodermal tumors (PNETs) are highly malignant neoplasms that usually affect the bones and soft tissues in children and young adults. ES/PNET of the lung is very rare and is associated with a poor prognosis. We herein report a case of ES/PNET of the left lung in a 45-year-old man. He was treated with neoadjuvant chemotherapy and pneumonectomy, but unfortunately his disease recurred 1.5 months after surgery. He was started on pazopanib, which resulted in a five-month progression-free survival. To our knowledge, this is the first demonstration of pazopanib efficacy in ES/PNET of the lung.

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© 2019 by The Japanese Society of Internal Medicine
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