The First Case Report of Acute Symptomatic HEV Genotype 4 Infection in an HIV-positive Patient in Japan

Satoshi Kitaura; Yoshitaka Wakabayashi; Aiko Okazaki; Yuta Okada; Koh Okamoto; Mahoko Ikeda; Shu Okugawa; Kyoji Moriya

doi:10.2169/internalmedicine.4505-20

CASE REPORTS

The First Case Report of Acute Symptomatic HEV Genotype 4 Infection in an HIV-positive Patient in Japan

Satoshi Kitaura, Yoshitaka Wakabayashi, Aiko Okazaki, Yuta Okada, Koh Okamoto, Mahoko Ikeda, Shu Okugawa, Kyoji Moriya

Author information

Satoshi Kitaura
Department of Infectious Diseases, The University of Tokyo Hospital, Japan
Yoshitaka Wakabayashi
Department of Infectious Diseases, The University of Tokyo Hospital, Japan
Department of Internal Medicine, Teikyo University, Japan
Aiko Okazaki
Department of Infectious Diseases, The University of Tokyo Hospital, Japan
Yuta Okada
Department of Infectious Diseases, The University of Tokyo Hospital, Japan
Koh Okamoto
Department of Infectious Diseases, The University of Tokyo Hospital, Japan
Mahoko Ikeda
Department of Infection Control and Prevention, The University of Tokyo, Japan
Shu Okugawa
Department of Infectious Diseases, The University of Tokyo Hospital, Japan
Kyoji Moriya
Department of Infectious Diseases, The University of Tokyo Hospital, Japan
Department of Infection Control and Prevention, The University of Tokyo, Japan

Keywords: hepatitis E, hepatitis E virus, human immunodeficiency virus, men who have sex with men

JOURNAL OPEN ACCESS

2020 Volume 59 Issue 13 Pages 1655-1658

DOI https://doi.org/10.2169/internalmedicine.4505-20

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Abstract

Hepatitis E virus (HEV) is a common cause of acute hepatitis. Four major genotypes of HEV have been studied, with genotype 4 being the predominant genotype across Asia. We herein describe the case of a 50-year-old man with a history of human immunodeficiency virus (HIV) infection who was admitted with acute transaminitis. Serum anti-HEV-IgA and HEV-RNA were detected at the time of presentation and further testing revealed HEV genotype 4. To the best of our knowledge, this represents the first clinical case report of acute symptomatic HEV genotype 4 infection in an HIV-positive patient in Japan.

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