Internal Medicine
Online ISSN : 1349-7235
Print ISSN : 0918-2918
ISSN-L : 0918-2918
CASE REPORTS
Anti-leucine-rich Glioma Inactivated-1 Encephalitis Associated with Essential Thrombocythemia
Xiaoling YuanXiaoyan ManJinbiao ZhangJijun SunJianhua LiangHongling MaShuxin TaoDong GuoLifeng Liu
Author information
JOURNALS OPEN ACCESS

2020 Volume 59 Issue 2 Pages 271-275

Details
Abstract

Anti-leucine-rich glioma inactivated-1 (anti-LGI1) encephalitis is a subgroup of autoimmune encephalitis. We herein report the case of a 60-year-old man who presented with typical symptoms, including short-term memory loss, mental abnormalities, hyponatremia and seizures characterized by faciobrachial dystonic seizures and who was diagnosed with anti-LGI1 encephalitis. At the same time, he was diagnosed with essential thrombocythemia. A significant improvement was obtained by treatment with corticosteroid, immunoglobulin, mycophenolate mofetil, and hydroxyurea. Autoimmune diseases are associated with a significantly increased risk of developing myeloproliferative neoplasms, which may explain the coexistence of anti-LGI1 encephalitis and essential thrombocythema in this patient; however, but more cases and studies are needed to determine whether there is any correlation between these conditions.

Information related to the author
© 2020 by The Japanese Society of Internal Medicine
Previous article Next article
feedback
Top