Internal Medicine
Online ISSN : 1349-7235
Print ISSN : 0918-2918
ISSN-L : 0918-2918
CASE REPORTS
T-cell Lymphoma Presenting Neutrophilic Inflammation in the Cerebrospinal Fluid
Takaaki NakamuraYoshiki TakaiKimihiko KanekoHiroshi KurodaTatsuro MisuKiyotaka AsanumaRyoko SaitoMasashi Aoki
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2020 年 59 巻 4 号 p. 573-576

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A 66-year-old woman presented with upper abdominal pain and weakness in the limbs. She had bilateral uveitis and gastric ulcers. A neurological examination revealed tetraparesis and sensory disturbance in the right arm. A cerebrospinal fluid (CSF) examination showed polymorphonuclear pleocytosis with elevated pro-inflammatory cytokine levels. Magnetic resonance imaging showed brain lesions and a long spinal cord lesion. She was initially diagnosed with neuro-Behçet's disease and was treated with corticosteroids, resulting in no improvement. A gastric mucosa biopsy indicated T-cell lymphoma colocalizing with neutrophils. The cytokine-mediated neutrophilic inflammation probably caused characteristic CSF and histopathological features. It is noteworthy that T-cell lymphoma may present with CSF neutrophilic inflammation.

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© 2020 by The Japanese Society of Internal Medicine
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