Two Cases of Severe COVID-19 Pneumonia Effectively Treated with Extracorporeal Membrane Oxygenation in Addition to Favipiravir and Corticosteroid

Masahiro Shinoda; Kenichi Kamachi; Shinichiro Ota; Lynn Yoshimatsu; Ryuichi Boku; Yuto Yoshida; Takatomo Hirouchi; Kanako Shinada; Takashi Sato; Miwa Morikawa; Koki Iwata; Takashi Matsumoto; Masaharu Shinkai

doi:10.2169/internalmedicine.5475-20

CASE REPORTS

Two Cases of Severe COVID-19 Pneumonia Effectively Treated with Extracorporeal Membrane Oxygenation in Addition to Favipiravir and Corticosteroid

Masahiro Shinoda, Kenichi Kamachi, Shinichiro Ota, Lynn Yoshimatsu, Ryuichi Boku, Yuto Yoshida, Takatomo Hirouchi, Kanako Shinada, Takashi Sato, Miwa Morikawa, Koki Iwata, Takashi Matsumoto, Masaharu Shinkai

Author information

Masahiro Shinoda
Department of Respiratory Medicine, Tokyo Shinagawa Hospital, Japan
Kenichi Kamachi
Department of Surgery, Tokyo Shinagawa Hospital, Japan
Shinichiro Ota
Department of Respiratory Medicine, Tokyo Shinagawa Hospital, Japan
Lynn Yoshimatsu
Department of Respiratory Medicine, Tokyo Shinagawa Hospital, Japan
Ryuichi Boku
Department of Emergency Medicine, Tokyo Shinagawa Hospital, Japan
Yuto Yoshida
Department of Respiratory Medicine, Tokyo Shinagawa Hospital, Japan
Takatomo Hirouchi
Department of Respiratory Medicine, Tokyo Shinagawa Hospital, Japan
Kanako Shinada
Department of Respiratory Medicine, Tokyo Shinagawa Hospital, Japan
Takashi Sato
Department of Respiratory Medicine, Tokyo Shinagawa Hospital, Japan
Miwa Morikawa
Department of Respiratory Medicine, Tokyo Shinagawa Hospital, Japan
Koki Iwata
Department of Emergency Medicine, Tokyo Shinagawa Hospital, Japan
Takashi Matsumoto
Department of Cardiology, Tokyo Shinagawa Hospital, Japan
Masaharu Shinkai
Department of Respiratory Medicine, Tokyo Shinagawa Hospital, Japan

Keywords: COVID-19, favipiravir, corticosteroid, extracorporeal membrane oxygenation, mechanical ventilation

JOURNAL OPEN ACCESS

2021 Volume 60 Issue 1 Pages 123-130

DOI https://doi.org/10.2169/internalmedicine.5475-20

Details

Abstract

Case 1: A 65-year-old man with novel coronavirus infection (COVID-19) complicated with acute respiratory failure. On admission, the patient was started on favipiravir and corticosteroid. However, due to a lack of significant improvement, he was introduced to mechanical ventilation and extracorporeal membrane oxygenation (ECMO). Although iliopsoas hematoma occurred as a complication, the patient recovered. Case 2: A 49-year-old man with COVID-19 had been started on favipiravir and corticosteroid. Due to progressive respiratory failure, the patient underwent mechanical ventilation and ECMO. The patient recovered without complications. We successfully treated these severe cases with a multimodal combination of pharmacological and non-pharmacological supportive therapy.

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