Internal Medicine
Online ISSN : 1349-7235
Print ISSN : 0918-2918
ISSN-L : 0918-2918
CASE REPORTS
A Kidney Transplant Patient Who Died of COVID-19-associated Severe Acute Respiratory Distress Syndrome
Akinari TsukadaManabu SuzukiYuya KishinoKento MisumiToru IgariNoriko NakajimaYuko SatoTadaki SuzukiTakashi KatsunoYusaku KusabaYoshie TsujimotoKeita SakamotoMasao HashimotoJunko TeradaJin TakasakiShinyu IzumiMasayuki HojoHaruhito Sugiyama
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JOURNAL OPEN ACCESS

2021 Volume 60 Issue 14 Pages 2297-2300

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Abstract

We herein report a 67-year-old kidney transplant patient who died of COVID-19. He was treated with hydroxychloroquine and azithromycin and received mechanical ventilation that temporarily improved his respiratory status. Despite our efforts, however, he later developed respiratory failure and died 43 days after the disease onset. The autopsy revealed prominent organization of alveoli and alveolar ducts, with a massive accumulation of macrophages in the lungs. A few severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) antigen-positive cells were detected in the lung, suggesting delayed virus clearance owing to his long-term immunosuppressed state, leading to constant lung damage and ultimately respiratory failure.

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© 2021 by The Japanese Society of Internal Medicine
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