Internal Medicine
Online ISSN : 1349-7235
Print ISSN : 0918-2918
ISSN-L : 0918-2918
CASE REPORTS
Severe Coronavirus Disease 2019 That Recovered from Respiratory Failure by Treatment That Included High-dose Intravenous Immunoglobulin
Yasuhito SuzukiYoshinori TaninoTakefumi NikaidoHiroyuki MinemuraTakashi UmedaMami RikimaruTakumi OnumaShotaro NaitoYoshinori TakiguchiHikaru TomitaTakaya KawamataRyuichi TogawaYuki SatoManabu UematsuJulia MorimotoKadzuhiro KitakawaYasuhiko TsukadaKiwamu NakamuraKeiji KanemitsuKen IsekiYoko Shibata
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JOURNAL OPEN ACCESS

2021 Volume 60 Issue 3 Pages 457-461

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Abstract

We herein report a case of severe coronavirus disease 2019 (COVID-19) in which high-dose intravenous immunoglobulin (IVIg) treatment achieved significant clinical improvement of deterioration of pulmonary inflammation after temporary clinical improvement. In the present case, clinical and radiological deterioration occurred despite a decrease in viral load, suggesting that deterioration was caused by reactivation of proinflammatory factors, such as tumor necrosis factor-α and interleukin-6, rather than direct viral effects. IVIg treatment may provide not only immunosuppressive effects but also inhibition of proinflammatory cytokines, indicating that treatment including IVIg may be effective by inhibiting cytokine storm in severe acute respiratory syndrome-coronavirus-2 (SARS-CoV-2) infection.

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© 2021 by The Japanese Society of Internal Medicine
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