The Association between Malignant Pleural Mesothelioma and Thoracic Radiation Therapy for Hodgkin's Lymphoma: The First Case Report in Japan

Koki Nakashima; Yoshiki Demura; Masahiro Oi; Mio Tabata; Toshihiko Tada; Kohei Shiozaki; Masaya Akai; Tamotsu Ishizuka

doi:10.2169/internalmedicine.5134-20

CASE REPORTS

The Association between Malignant Pleural Mesothelioma and Thoracic Radiation Therapy for Hodgkin's Lymphoma: The First Case Report in Japan

Koki Nakashima, Yoshiki Demura, Masahiro Oi, Mio Tabata, Toshihiko Tada, Kohei Shiozaki, Masaya Akai, Tamotsu Ishizuka

Author information

Koki Nakashima
Department of Respiratory Medicine, Japanese Red Cross Fukui Hospital, Japan
Third department of Internal Medicine, Faculty of Medical Sciences, University of Fukui, Japan
Yoshiki Demura
Department of Respiratory Medicine, Japanese Red Cross Fukui Hospital, Japan
Masahiro Oi
Department of Respiratory Medicine, Japanese Red Cross Fukui Hospital, Japan
Mio Tabata
Department of Respiratory Medicine, Japanese Red Cross Fukui Hospital, Japan
Toshihiko Tada
Department of Respiratory Medicine, Japanese Red Cross Fukui Hospital, Japan
Kohei Shiozaki
Department of Respiratory Medicine, Japanese Red Cross Fukui Hospital, Japan
Masaya Akai
Department of Respiratory Medicine, Japanese Red Cross Fukui Hospital, Japan
Tamotsu Ishizuka
Third department of Internal Medicine, Faculty of Medical Sciences, University of Fukui, Japan

Keywords: malignant pleural mesothelioma, radiation, thoracic radiation, Hodgkin's lymphoma, secondary malignancy

JOURNAL OPEN ACCESS

2021 Volume 60 Issue 5 Pages 771-775

DOI https://doi.org/10.2169/internalmedicine.5134-20

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Abstract

Malignant pleural mesothelioma (MPM) is mostly observed in patients with a history of asbestos exposure. Although other causes are rare, there are several reports of MPM induced by therapeutic radiation, mainly in Europe and North America. However, no such case has been reported in Japan. We herein report a 50-year-old Japanese woman who developed MPM 25 years after thoracic radiation therapy for Hodgkin's lymphoma. The patient had no history of exposure to asbestos; therefore, her history of radiation therapy was considered to be the cause of MPM. Clinicians should consider secondary MPM in patients with a history of thoracic radiation therapy.

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