Internal Medicine
Online ISSN : 1349-7235
Print ISSN : 0918-2918
ISSN-L : 0918-2918
CASE REPORTS
Successful Treatment with Benralizumab for Allergic Bronchopulmonary Aspergillosis That Developed after Disastrous Heavy Rainfall in Western Japan
Hiroaki MatsuuraKeiichi FujiwaraHiroki OmoriKiriko OnishiTadahiro KuribayashiSho MitsumuneYuki TakigawaKenichiro KudoDaisuke MinamiAkiko SatoKen SatoTakuo Shibayama
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2021 Volume 60 Issue 9 Pages 1443-1450

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Abstract

We herein report a 56-year-old woman who developed allergic bronchopulmonary aspergillosis (ABPA) possibly due to fungal exposure after disastrous heavy rainfall in Western Japan in 2018. She was diagnosed with ABPA complicated with asthma, increased peripheral blood eosinophil count, elevation of specific immunoglobulin E for Aspergillus fumigatus, positive Aspergillus fumigatus precipitation antibody reaction test results, and notable chest computed tomography findings. After treatment with benralizumab, her symptoms, peripheral blood eosinophil count, radiological findings, and respiratory function dramatically improved. The administration of benralizumab appears to be an effective treatment strategy for ABPA.

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© 2021 by The Japanese Society of Internal Medicine
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