Hypercalcemia Associated with the Ectopic Expression of 25-hydroxyvitamin D3-1α-hydroxylase in Diffuse Large B-cell Lymphoma

Masashi Ogawa; Maho Morikawa; Masaki Kobatake; Taku Murakami; Yuki Yamamoto; Rikiya Watanabe; Katsumi Yamada; Katsuhito Nishiyama; Yoshiro Yasutomo; Kenta Hara

doi:10.2169/internalmedicine.8933-21

CASE REPORTS

Hypercalcemia Associated with the Ectopic Expression of 25-hydroxyvitamin D3-1α-hydroxylase in Diffuse Large B-cell Lymphoma

Masashi Ogawa, Maho Morikawa, Masaki Kobatake, Taku Murakami, Yuki Yamamoto, Rikiya Watanabe, Katsumi Yamada, Katsuhito Nishiyama, Yoshiro Yasutomo, Kenta Hara

Author information

Masashi Ogawa
Department of Diabetes and Endocrine Disease, Kita-Harima Medical Center, Japan
Maho Morikawa
Department of Diabetes and Endocrine Disease, Kita-Harima Medical Center, Japan
Masaki Kobatake
Department of Diabetes and Endocrine Disease, Kita-Harima Medical Center, Japan
Taku Murakami
Department of Diabetes and Endocrine Disease, Kita-Harima Medical Center, Japan
Yuki Yamamoto
Department of Diagnostic Pathology, Kita-Harima Medical Center, Japan
Rikiya Watanabe
Department of Internal and Geriatric Medicine, Kita-Harima Medical Center, Japan
Katsumi Yamada
Department of Internal and Geriatric Medicine, Kita-Harima Medical Center, Japan
Katsuhito Nishiyama
Department of Diabetes and Endocrine Disease, Kita-Harima Medical Center, Japan
Yoshiro Yasutomo
Department of Diabetes and Endocrine Disease, Kita-Harima Medical Center, Japan
Kenta Hara
Department of Diabetes and Endocrine Disease, Kita-Harima Medical Center, Japan

Keywords: calcium, 1,25 (OH) ₂VitD, 1α-hydroxylase, CYP27B1, lymphoma

JOURNAL OPEN ACCESS

2022 Volume 61 Issue 16 Pages 2489-2495

DOI https://doi.org/10.2169/internalmedicine.8933-21

Details

Abstract

An 82-year-old man was transferred to our hospital due to impaired consciousness. His albumin-corrected calcium level was 14.2 mg/dL, intact parathyroid hormone (PTH) and PTH-related protein levels were reduced, and his 1,25-dihydroxyvitamin D [1,25 (OH) ₂VitD] level was elevated at 71.5 pg/mL. Computed tomography revealed masses on the bilateral ribs. The mass on the rib was biopsied and diagnosed as diffuse large B-cell lymphoma (DLBCL). Immunostaining of the biopsy sample with the anti-CYP27B1 antibody revealed the ectopic expression of 1α-hydroxylase in the lesion. We herein report a rare case of hypercalcemia induced by the overproduction of 1,25 (OH) ₂VitD in DLBCL ectopically expressing 1α-hydroxylase.

Corresponding author

Register with J-STAGE for free!