Secondary Skin Cancer in a Case with Long-term Voriconazole after Allogeneic Hematopoietic Stem Cell Transplantation for Acute Myeloid Leukemia

Noriaki Kawano; Shunou Nakamura; Kousuke Mochida; Shuro Yoshida; Takuro Kuriyama; Takashi Nakaike; Tomonori Shimokawa; Taro Tochigi; Kiyoshi Yamashita; Koichi Mashiba; Ikuo Kikuchi; Aina Takarabe; Sayaka Moriguchi; Yasuo Mori; Katsuto Takenaka; Kazuya Shimoda; Hidenobu Ochiai; Masahiro Amano

doi:10.2169/internalmedicine.8618-21

CASE REPORTS

Secondary Skin Cancer in a Case with Long-term Voriconazole after Allogeneic Hematopoietic Stem Cell Transplantation for Acute Myeloid Leukemia

Noriaki Kawano, Shunou Nakamura, Kousuke Mochida, Shuro Yoshida, Takuro Kuriyama, Takashi Nakaike, Tomonori Shimokawa, Taro Tochigi, Kiyoshi Yamashita, Koichi Mashiba, Ikuo Kikuchi, Aina Takarabe, Sayaka Moriguchi, Yasuo Mori, Katsuto Takenaka, Kazuya Shimoda, Hidenobu Ochiai, Masahiro Amano

Author information

Noriaki Kawano
Department of Internal Medicine, Miyazaki Prefectural Miyazaki Hospital, Japan
Shunou Nakamura
Department of Dermatology, Faculty of Medicine, University of Miyazaki, Japan
Kousuke Mochida
Department of Dermatology, Faculty of Medicine, University of Miyazaki, Japan
Shuro Yoshida
Department of Internal Medicine, Miyazaki Prefectural Miyazaki Hospital, Japan
Takuro Kuriyama
Department of Internal Medicine, Miyazaki Prefectural Miyazaki Hospital, Japan
Takashi Nakaike
Department of Internal Medicine, Miyazaki Prefectural Miyazaki Hospital, Japan
Tomonori Shimokawa
Department of Internal Medicine, Miyazaki Prefectural Miyazaki Hospital, Japan
Taro Tochigi
Department of Internal Medicine, Miyazaki Prefectural Miyazaki Hospital, Japan
Kiyoshi Yamashita
Department of Internal Medicine, Miyazaki Prefectural Miyazaki Hospital, Japan
Koichi Mashiba
Department of Internal Medicine, Miyazaki Prefectural Miyazaki Hospital, Japan
Ikuo Kikuchi
Department of Internal Medicine, Miyazaki Prefectural Miyazaki Hospital, Japan
Aina Takarabe
Department of Dermatology, Miyazaki Prefectural Miyazaki Hospital, Japan
Sayaka Moriguchi
Department of Pathology, Miyazaki Prefectural Miyazaki Hospital, Japan
Yasuo Mori
Department of Medicine and Biosystemic Science, Graduate School of Medical Sciences, Kyushu University, Japan
Katsuto Takenaka
Department of Hematology, Clinical Immunology and Infectious Diseases, Ehime University Graduate School of Medicine, Japan
Kazuya Shimoda
Division of Hematology, Diabetes, and Endocrinology, Department of Internal Medicine, Faculty of Medicine, University of Miyazaki, Japan
Hidenobu Ochiai
Trauma and Critical Care Center, Faculty of Medicine, University of Miyazaki, Japan
Masahiro Amano
Department of Dermatology, Faculty of Medicine, University of Miyazaki, Japan

Keywords: secondary skin cancer, allo-HSCT, voriconazole, chronic GVHD

JOURNAL OPEN ACCESS

2022 Volume 61 Issue 18 Pages 2771-2774

DOI https://doi.org/10.2169/internalmedicine.8618-21

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Abstract

Secondary malignancies that develop after allogeneic-hematopoietic stem cell transplantation (allo-HSCT) have become serious issues. A 47-year-old man who developed acute myeloid leukemia in 2009 and subsequently underwent allo-HSCT twice: in 2009 and 2011. In 2015, voriconazole for lung aspergillus was started. In 2018, chronic graft-versus-host disease (GVHD) and multiple actinic keratoses manifested at his head. In 2020, some lesions were diagnosed as squamous cell carcinoma, so voriconazole was withdrawn, and subsequent surgery and radiation led to remission. Long-term administration of voriconazole in addition to allo-HSCT and chronic GVHD may be closely related to secondary skin cancer.

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