Lenvatinib-induced Interstitial Pneumonia in a Patient with Hepatocellular Carcinoma

Takeshi Imakura; Seidai Sato; Tetsu Tomonari; Kojin Murakami; Naoki Takahashi; Nobuhito Naito; Masato Mima; Kozo Kagawa; Kazuya Koyama; Haruka Nishimura; Hiroshi Kawano; Hiroshi Nokihara; Masahiko Azuma; Tetsuji Takayama; Yasuhiko Nishioka

doi:10.2169/internalmedicine.7300-21

CASE REPORTS

Lenvatinib-induced Interstitial Pneumonia in a Patient with Hepatocellular Carcinoma

Takeshi Imakura, Seidai Sato, Tetsu Tomonari, Kojin Murakami, Naoki Takahashi, Nobuhito Naito, Masato Mima, Kozo Kagawa, Kazuya Koyama, Haruka Nishimura, Hiroshi Kawano, Hiroshi Nokihara, Masahiko Azuma, Tetsuji Takayama, Yasuhiko Nishioka

Author information

Takeshi Imakura
Department of Respiratory Medicine and Rheumatology, Graduate School of Biomedical Sciences, Tokushima University, Japan
Seidai Sato
Department of Respiratory Medicine and Rheumatology, Graduate School of Biomedical Sciences, Tokushima University, Japan
Tetsu Tomonari
Department of Gastroenterology and Oncology, Graduate School of Biomedical Sciences, Tokushima University, Japan
Kojin Murakami
Department of Respiratory Medicine and Rheumatology, Graduate School of Biomedical Sciences, Tokushima University, Japan
Naoki Takahashi
Department of Respiratory Medicine and Rheumatology, Graduate School of Biomedical Sciences, Tokushima University, Japan
Nobuhito Naito
Department of Respiratory Medicine and Rheumatology, Graduate School of Biomedical Sciences, Tokushima University, Japan
Masato Mima
Department of Respiratory Medicine and Rheumatology, Graduate School of Biomedical Sciences, Tokushima University, Japan
Kozo Kagawa
Department of Respiratory Medicine and Rheumatology, Graduate School of Biomedical Sciences, Tokushima University, Japan
Kazuya Koyama
Department of Respiratory Medicine and Rheumatology, Graduate School of Biomedical Sciences, Tokushima University, Japan
Haruka Nishimura
Department of Respiratory Medicine and Rheumatology, Graduate School of Biomedical Sciences, Tokushima University, Japan
Hiroshi Kawano
Department of Respiratory Medicine and Rheumatology, Graduate School of Biomedical Sciences, Tokushima University, Japan
Department of Community Medicine for Rheumatology, Graduate School of Biomedical Sciences, Tokushima University, Japan
Hiroshi Nokihara
Department of Respiratory Medicine and Rheumatology, Graduate School of Biomedical Sciences, Tokushima University, Japan
Masahiko Azuma
Department of Respiratory Medicine and Rheumatology, Graduate School of Biomedical Sciences, Tokushima University, Japan
Department of Medical Education, Graduate School of Biomedical Sciences, Tokushima University, Japan
Tetsuji Takayama
Department of Gastroenterology and Oncology, Graduate School of Biomedical Sciences, Tokushima University, Japan
Yasuhiko Nishioka
Department of Respiratory Medicine and Rheumatology, Graduate School of Biomedical Sciences, Tokushima University, Japan
Department of Community Medicine for Rheumatology, Graduate School of Biomedical Sciences, Tokushima University, Japan

Keywords: lenvatinib, interstitial pneumonia, hepatocellular carcinoma

JOURNAL OPEN ACCESS

2022 Volume 61 Issue 8 Pages 1211-1217

DOI https://doi.org/10.2169/internalmedicine.7300-21

Browse “Advance online publication” version

Details

Abstract

Lenvatinib is a multi-targeted tyrosine kinase inhibitor available for the treatment of unresectable hepatocellular carcinoma (HCC). We herein report an 84-year-old-man with interstitial pneumonia caused by lenvatinib. Four months after the start of lenvatinib administration for HCC, chest computed tomography revealed bilateral ground-glass opacity. However, he continued to take lenvatinib for four more months until he complained of dyspnea on exertion. This is a case of lenvatinib-induced interstitial pneumonia that progressed relatively slowly with a long asymptomatic period despite the appearance of pneumonia on image findings.

Corresponding author

Register with J-STAGE for free!