Internal Medicine
Online ISSN : 1349-7235
Print ISSN : 0918-2918
ISSN-L : 0918-2918
CASE REPORTS
Atypical Cogan's Syndrome Mimicking Giant Cell Arteritis Successfully Treated with Early Administration of Tocilizumab
Kazusato HaraMasataka UmedaKeiko SegawaMidori AkagiYushiro EndoTomohiro KogaShin-ya KawashiriKunihiro IchinoseHideki NakamuraTakahiro MaedaAtsushi Kawakami
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JOURNAL OPEN ACCESS

2022 Volume 61 Issue 8 Pages 1265-1270

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Abstract

A 49-year-old Japanese man with a 2-month history of a fever, headache, and bilateral conjunctival hyperemia was admitted. His condition fulfilled the giant cell arteritis classification criteria (new headache, temporal artery tenderness, elevated ESR) and atypical Cogan's syndrome (CS) with scleritis and sensorineural hearing loss (SNHL). The interleukin (IL)-6 serum level was extremely high. Two weeks after his insufficient response of SNHL and scleritis to oral prednisolone, we administered tocilizumab (TCZ); rapid improvements in scleritis and SNHL occurred. Early IL-6 target therapy can help prevent irreversible CS-induced sensory organ damage.

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© 2022 by The Japanese Society of Internal Medicine
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