Internal Medicine
Online ISSN : 1349-7235
Print ISSN : 0918-2918
ISSN-L : 0918-2918
CASE REPORTS
Autoimmune Pulmonary Alveolar Proteinosis That Improved after a COVID-19 Episode
Atsushi YanagisawaTakayuki TakimotoRyota ShintaniTakehiko KobayashiMasaki HiroseToru AraiYoshikazu Inoue
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JOURNAL OPEN ACCESS

2023 Volume 62 Issue 15 Pages 2237-2241

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Abstract

Autoimmune pulmonary alveolar proteinosis (APAP) is caused by macrophage dysfunction owing to the presence of anti-granulocyte-macrophage colony-stimulating factor (GM-CSF) autoantibodies. A 77-year-old man with APAP was referred to our hospital for whole-lung lavage (WLL) due to oxygenation exacerbation and pulmonary shadows. The patient had had coronavirus disease 2019 (COVID-19) during the APAP evaluation before WLL. About three months after COVID-19 resolved, his oxygenation and shadow reflecting APAP had obviously improved, thus avoiding the need for WLL. We suspected that the improvement in APAP was due to various immunological reactions induced by COVID-19.

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© 2023 by The Japanese Society of Internal Medicine
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