Internal Medicine
Online ISSN : 1349-7235
Print ISSN : 0918-2918
ISSN-L : 0918-2918
CASE REPORTS
New-onset Adult-onset Still's Disease Following COVID-19 Vaccination: Three Case Reports and a Literature Review
Mayumi MatsudaYu Funakubo AsanumaKazuhiro YokotaSakon SakaiHiroaki YazawaTakashi MaruyamaTakuma Tsuzuki WadaYasuto ArakiToshihide Mimura
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JOURNAL OPEN ACCESS

2023 Volume 62 Issue 2 Pages 299-305

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Abstract

Since December 2020, coronavirus disease 2019 (COVID-19) vaccines have been distributed in most countries to prevent the onset and aggravation of COVID-19. There is little information regarding the long-term safety of the vaccines. We report three cases and a literature review of new-onset adult-onset Still's disease (AOSD) that occurred following COVID-19 vaccination. Our cases include moderate to severe AOSD, and two were complicated with macrophage activation syndrome. Seventeen cases of new-onset or relapse of AOSD following COVID-19 vaccination, including 14 identified in the literature review and our 3 patients, were all treated successfully with glucocorticoid therapy, immunosuppressive drugs, or biologic agents.

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© 2023 by The Japanese Society of Internal Medicine
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