Internal Medicine
Online ISSN : 1349-7235
Print ISSN : 0918-2918
ISSN-L : 0918-2918
CASE REPORTS
Clinicopathologic Features of Adult-onset Still's Disease Complicated by Severe Liver Injury
Miho KurokawaTomonobu HiokiTomomi AoyagiMotoi TakahashiKoji ImotoTakeshi GoyaMasatake TanakaMotoyuki KohjimaYoshihiro Ogawa
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JOURNAL OPEN ACCESS
Supplementary material

2024 Volume 63 Issue 4 Pages 503-511

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Abstract

Adult-onset Still's disease (AOSD) is a systemic inflammatory disorder. Severe liver injury has rarely been reported, although liver enzyme elevation is a common complication of AOSD. We herein report four cases of relapsed AOSD with severe liver disorder by tapering or terminating corticosteroids. Liver specimens revealed robust infiltration of inflammatory cells throughout the lobule, especially cluster of differentiation (CD) 8-positive cells. Relapsed AOSD was refractory to corticosteroid reintroduction and required immunosuppressants. Severe liver injury with AOSD is pathologically characterized by extensive lobular infiltration of CD8-positive cells, and we should consider additive immunosuppressive agents on corticosteroids for treatment.

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© 2024 by The Japanese Society of Internal Medicine

This article is licensed under a Creative Commons [Attribution-NonCommercial-NoDerivatives 4.0 International] license.
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