Internal Medicine
Online ISSN : 1349-7235
Print ISSN : 0918-2918
Pancreatic Acinar Cell Carcinoma with Multiple Liver Metastases Effectively Treated by S-1 Chemotherapy
Naoki YoshidaAtsushi KannoAtsushi MasamuneTatsuhide NabeshimaSeiji HongoShin MiuraTetsuya TakikawaShin HamadaKazuhiro KikutaKiyoshi KumeMasamichi UenoTooru Shimosegawa
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JOURNALS OPEN ACCESS Advance online publication

Article ID: 0294-17


A 79-year-old woman was referred for pancreatic tail cancer with multiple liver metastases. The pancreatic tail tumor was diagnosed as acinar cell carcinoma (ACC) histologically by endoscopic ultrasound-guided fine-needle aspiration. Because of multiple liver metastases, S-1 chemotherapy was administered, resulting in a partial response to chemotherapy one year later. After approximately three years, liver atrophy and esophageal varices developed. We suspected S-1 as the cause of the liver cirrhosis. S-1 cessation minimized ascites and improved the esophageal varices. Although S-1 can potentially treat ACC, we should be watchful for liver cirrhosis caused by its long-term administration.

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© 2019 by The Japanese Society of Internal Medicine
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