Successful Cord Blood Stem Cell Transplantation for Primary Cutaneous CD8-positive Aggressive Epidermotropic Cytotoxic T-cell Lymphoma Complicated with Cerebral Infiltration

Satoshi Ichikawa; Noriko Fukuhara; Shunsuke Hatta; Masahito Himuro; Hiroki Katsushima; Kentaro Nasu; Koya Ono; Kyoko Inokura; Masahiro Kobayashi; Yasushi Onishi; Hiroshi Fujii; Kenichi Ishizawa; Ryo Ichinohasama; Hideo Harigae

doi:10.2169/internalmedicine.0568-17

This article has now been updated. Please use the final version.

Successful Cord Blood Stem Cell Transplantation for Primary Cutaneous CD8-positive Aggressive Epidermotropic Cytotoxic T-cell Lymphoma Complicated with Cerebral Infiltration

Satoshi Ichikawa, Noriko Fukuhara, Shunsuke Hatta, Masahito Himuro, Hiroki Katsushima, Kentaro Nasu, Koya Ono, Kyoko Inokura, Masahiro Kobayashi, Yasushi Onishi, Hiroshi Fujii, Kenichi Ishizawa, Ryo Ichinohasama, Hideo Harigae

Author information

Satoshi Ichikawa
Department of Hematology and Rheumatology, Tohoku University Hospital, Japan
Noriko Fukuhara
Department of Hematology and Rheumatology, Tohoku University Hospital, Japan
Shunsuke Hatta
Department of Hematology and Rheumatology, Tohoku University Hospital, Japan
Masahito Himuro
Department of Hematology and Rheumatology, Tohoku University Hospital, Japan
Hiroki Katsushima
Department of Hematopathology, Tohoku University Hospital, Japan
Kentaro Nasu
Department of Hematology and Rheumatology, Tohoku University Hospital, Japan
Koya Ono
Department of Hematology and Rheumatology, Tohoku University Hospital, Japan
Kyoko Inokura
Department of Hematology and Cell Therapy, Yamagata University Faculty of Medicine, Japan
Masahiro Kobayashi
Department of Hematology and Rheumatology, Tohoku University Hospital, Japan
Yasushi Onishi
Department of Hematology and Rheumatology, Tohoku University Hospital, Japan
Hiroshi Fujii
Department of Hematology and Rheumatology, Tohoku University Hospital, Japan
Kenichi Ishizawa
Department of Hematology and Cell Therapy, Yamagata University Faculty of Medicine, Japan
Ryo Ichinohasama
Department of Hematopathology, Tohoku University Hospital, Japan
Hideo Harigae
Department of Hematology and Rheumatology, Tohoku University Hospital, Japan

Keywords: primary cutaneous CD8-positive aggressive epidermotropic cytotoxic T-cell lymphoma, cerebral infiltration, cord blood transplantation

JOURNAL OPEN ACCESS Advance online publication

Article ID: 0568-17

DOI https://doi.org/10.2169/internalmedicine.0568-17

The final version of this article is now available: Vol. 57 (2018), No. 14 pp. 2051-2055

Details

Abstract

A 16-year-old boy, who had been initially examined for bilateral blepharedema and slight eruption, presented with rapidly deteriorating symptoms in associating with headache and consciousness disturbance. He was diagnosed to have primary cutaneous CD8-positive aggressive epidermotropic cytotoxic T-cell lymphoma (PCAE-CTL) by a biopsy of the skin and brain. After whole-brain radiation and some courses of chemotherapy, cord blood transplantation was performed with myeloablative conditioning. After transplantation, the cerebral dysfunction gradually improved. Disease remission was confirmed by the disappearance of any abnormal findings on electroencephalogram and magnetic resonance imaging. PCAE-CTL is reported to be an extremely aggressive disease with a poor prognosis, but the timely performance of cord blood transplantation is considered to be a promising treatment strategy.

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